Hepatitis B immunoglobulin for newborn side effects

Case Reports

. 2010 Oct;23(10):1257-9.

doi: 10.3109/14767051003653260.

Affiliations

  • PMID: 20210693
  • DOI: 10.3109/14767051003653260

Case Reports

Anaphylactic shock due to hepatitis B immunoglobulin in a newborn

Ali Bulbul et al. J Matern Fetal Neonatal Med. 2010 Oct.

Abstract

Hepatitis B immunoglobulin (HBIG) is administered for the passive immunisation of all infants born to HBsAg-positive mothers within 12 h of birth. Adverse effects of HBIG are very rare. In this study, we report a newborn (a female, 33 weeks' gestation and 2030 g birth weight) developing anaphylaxis after HBIG administration. The mother was a Hepatitis B virus (HBV) carrier. Hypotension and erythematous rash developed 7 min after HBIG administration. Reporting the first anaphylaxis case in newborns due to HBIG in literature, we suggest the condition be taken into account, and requisite precautions should be taken against this probable complication in the newborn.

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What are the side effects of Hep B vaccine in newborns?

The most common side effects of the hepatitis B vaccine are mild and include: Low fever (less than 101 degrees) or, Sore arm from the shot.
All babies should get the first shot of hepatitis B vaccine within 24 hours of birth. This shot reduces the risk of your baby getting the disease from you or family members who may not know they are infected with hepatitis B.

Why do babies not need Hep B vaccine?

A dose given to a new born even after six months will be as effective since most babies are naturally immune to Hepatitis-B infection due to passive transfer of antibodies from the mother.

What is the purpose of hepatitis B immunoglobulin?

Hepatitis B immune globulin (Human) injection is used to prevent hepatitis B from occurring again in HBsAg-positive liver transplant patients who have had liver transplants. This medicine also helps keep you from getting sick if you have been exposed to hepatitis B virus.