How long does it take for the anaesthetic gel instilled into the urethra to take effect?
Dosing & UsesAdultPediatric Show
Dosage Forms & Strengthstopical jelly
topical gel
topical cream
topical ointment
topical lotion
topical spray
topical solution, mouth/throat
Anesthetic Lubricant for IntubationIndicated as an anesthetic lubricant for oral or nasal endotracheal intubation Jelly (2%): Apply moderate amount to external surface of endotracheal tube shortly before use Ointment: Apply to tube prior to intubation Not to exceed 600 mg/12 hr Urethral Surface AnesthesiaWhen using Xylocaine 2% Jelly 30 mL tubes for urologic procedures, sterilize the plastic cone for 5 minutes in boiling water, cool, and attach to the tube Females
Males
Premature EjaculationTemporarily reduces sensitivity of the penis, which helps to delay ejaculation Epic, Premject, Promescent: Apply 3 or more sprays (10 mg/spray), not to exceed 10 sprays, to the head and shaft of the penis before intercourse Wash product off after intercourse Correct quantity and time of application will be determined by individual requirements; use the minimum effective quantity Do not exceed 24 sprays/24 hr Skin IrritationIndicated for temporary relief of pain and itching caused by minor skin irritations (eg, sunburn, minor burns, minor cuts, scrapes, insect bites, minor skin irritations) Apply topically to affected area TID/QID Dosage Forms & Strengthstopical jelly
topical gel
topical cream
topical ointment
topical lotion
topical spray
topical solution, mouth/throat
Anesthetic Lubricant for IntubationIndicated as an anesthetic lubricant for oral or nasal endotracheal intubation Jelly (2%): Apply moderate amount to external surface of endotracheal tube shortly before use Ointment: Apply to tube prior to intubation Children aged <10 years: Not to exceed 4.5 mg/kg per 12 hr Older children/adolescents: Not to exceed 600 mg/12 hr Skin IrritationIndicated for temporary relief of pain and itching caused by minor skin irritations (eg, sunburn, minor burns, minor cuts, scrapes, insect bites, minor skin irritations) <2 years: Safety and efficacy not established ≥2 years: Apply topically to affected area TID/QID Frequency Not DefinedCardiovascular (with excessive systemic absorption): CV depressant effect characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest Allergic: Cutaneous lesions, urticaria, edema, or anaphylactoid reactions Central nervous system
WarningsBlack Box WarningsSignificant systemic absorption may occur with topical use Twenty-two case reports have shown evidence of serious adverse reaction when viscous lidocaine 2% is used in young children to treat mouth pain Resulting reactions include seizures, severe brain injury, and cardiovascular depression characterized by bradycardia, hypotension, and cardiovascular collapse, which may lead to cardiac arrest ContraindicationsHypersensitivity to drug or amide type anesthetic CautionsSome formulations may contain sulfites Contact with eye may cause severe eye irritation; if eye contact occurs, immediately wash out the eye with water or saline and protect eye until sensation returns Patients with severe hepatic disease are at greater risk of developing toxic blood concentrations of lidocaine due to inability to metabolize lidocaine normally When used concomitantly with other products containing local anesthetic agents, the amount of lidocaine absorbed from all formulations must be considered Application to broken or inflamed skin, although not tested, may result in higher blood concentrations of lidocaine from increased absorption; apply only to intact skin Jelly for endotracheal use
Excessive systemic absorption
2% Viscous solution
Pregnancy & LactationPregnancyThere are no available data regarding use in pregnant women Reproduction studies with lidocaine have been performed in rats at doses up to 30 mg/kg SC and have revealed no evidence of harm to the fetus due to lidocaine There are, however, no adequate and well-controlled studies in pregnant women Because animal reproduction studies are not always predictive of human response, should be used during pregnancy only if clearly needed LactationThere are no available data regarding use in breastfeeding women; caution if administered Lidocaine is excreted in human milk, and the milk: plasma ratio of lidocaine is 0.4 Pregnancy CategoriesA: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk. B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available. PharmacologyMechanism of ActionElicits local anesthesia; stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action AbsorptionOnset of action: 3-5 minutes (eg, gel, cream, ointment) MetabolismIt is not known if lidocaine is metabolized in the skin Lidocaine is metabolized rapidly by the liver to a number of metabolites, including monoethylglycinexylidide (MEGX) and glycinexylidide (GX), both of which have pharmacologic activity similar to, but less potent than that of lidocaine EliminationHalf-life: 81-149 minutes (IV) Total body clearance: 0.33-0.9 L/min Excretion: Kidneys (<10% unchanged) ImagesNo images available for this drug. Patient HandoutA Patient Handout is not currently available for this monograph. FormularyFormularyPatient Discounts Adding plans allows you to compare formulary status to other drugs in the same class. To view formulary information first create a list of plans. Your list will be saved and can be edited at any time. Adding plans allows you to:
The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. View explanations for tiers and restrictions
Non-Medicare Plans Medicare Plans From: To: The recipient will receive more details and instructions to access this offer. By clicking send, you acknowledge that you have permission to email the recipient with this information. From: To: The recipient will receive more details and instructions to access this offer. By clicking send, you acknowledge that you have permission to email the recipient with this information. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. How long does it take for the anaesthetic lubricating gel instilled into the urethra to take effect?Instillagel 11 ml is used in male catheterization. After the nozzle is inserted, instil 11 ml of Instillagel slowly to dilate the urethra. Instillagel provides excellent lubrication, and has proven anaesthetic and antiseptic properties. The anaesthetic effect takes 3–5 minutes to develop.
How is numbing gel applied urethra?Urethral lubrication can be performed in two different techniques: instillation of the gel directly into the urethra or pouring the gel on the catheter's tip. In this study, we will evaluate the pain level during female urethral catheterization in each technique.
Does numbing gel work for cystoscopy?local anaesthetic gel is applied to your urethra to numb it and help the cystoscope move along it more easily. the cystoscope is inserted into your urethra and gently moved down towards your bladder.
What is the main purpose of using lidocaine hydrochloride gel in male urethral catheterisation?The use of lubricants in urethral catheterization can minimize urethral trauma, reduce the risk of infection, and minimize pain and discomfort during the operation, especially when using a lubricant containing local anesthetic.
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