Which of the following brain structures is most associated with the emotion of fear?

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In the 1970s, anthropologist Paul Ekman proposed that humans experienced six basic emotions: anger, fear, surprise, disgust, joy, and sadness. Since then, scientists have disputed the exact number of human emotions — some researchers maintain there are only four, while others count as many as 27. And, scientists also debate whether they are universal to all human cultures and whether we’re born with them or learn them through experience. Even the definition of emotion is a topic of controversy. One thing is clear though — emotions arise from activity in distinct regions of the brain.

Three brain structures appear most closely linked with emotions: the amygdala, the insula or insular cortex, and a structure in the midbrain called the periaqueductal gray.

A paired, almond-shaped structure deep within the brain, the amygdala integrates emotions, emotional behavior, and motivation. It interprets fear, helps distinguish friends from foes, and identifies social rewards and how to attain them. The amygdala is also important for a type of learning called classical conditioning. Russian physiologist Ivan Pavlov first described classical conditioning, where, through repeated exposure, a stimulus elicits a particular response, in his studies of digestion in dogs. The dogs salivated when a lab technician brought them food. Over time, Pavlov noted the dogs also began to salivate at the mere sight of the technician, even if he was empty-handed.

The insula is the source of disgust — a strong negative reaction to an unpleasant odor, for instance. The experience of disgust may protect you from ingesting poison or spoiled food. Studies using magnetic resonance imaging (MRI) have found the insula lights up with activity when someone feels or anticipates pain. Neuroscientists think the insula receives a status report about the body’s physiological state and generates subjective feelings about it thus linking internal states, feelings, and conscious actions.

The periaqueductal gray, located in the brainstem, has also been implicated in pain perception. It contains receptors for pain-reducing compounds like morphine and oxycodone, and can help quell activity in pain-sensing nerves — it might be part of the reason you can sometimes distract yourself from pain so you don’t feel it as acutely. The periaqueductal gray is also involved in defensive and reproductive behaviors, maternal attachment, and anxiety.

While emotions are intangible and hard to describe — even for scientists — they serve important purposes, helping us learn, initiate actions, and survive.

Adapted from the 8th edition of Brain Facts by Alexis Wnuk

About the Author

Deborah Halber

Deborah Halber is a Boston-based author, science writer and journalist. Her work has appeared in The Atlantic, Time.com, The Boston Globe, MIT Technology Review, Boston magazine, and university publications.

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References

Craig ADB. 2009. How do you feel--now? The anterior insula and human awareness. Nat Rev Neurosci. 10(1):59–70. doi:10.1038/nrn2555.

Linnman C, Moulton EA, Barmettler G, Becerra L, Borsook D. 2012. Neuroimaging of the Periaqueductal Gray: State of the Field. Neuroimage. 60(1):505–522. doi:10.1016/j.neuroimage.2011.11.095.

The image on the left is a side view of the outside of the brain, showing the major lobes (frontal, parietal, temporal and occipital) and the brain stem structures (pons, medulla oblongata, and cerebellum).

The image on the right is a side view showing the location of the limbic system inside the brain. The limbic system consists of a number of structures, including the fornix, hippocampus, cingulate gyrus, amygdala, the parahippocampal gyrus, and parts of the thalamus. The hippocampus is one of the first areas affected by Alzheimer's disease. As the disease progresses, damage extends throughout the lobes.

Glossary of Terms

Amygdala: Limbic structure involved in many brain functions, including emotion, learning and memory. It is part of a system that processes "reflexive" emotions like fear and anxiety.

Cerebellum: Governs movement.

Cingulate Gyrus: Plays a role in processing conscious emotional experience.

Fornix: An arch-like structure that connects the hippocampus to other parts of the limbic system.

Frontal Lobe: Helps control skilled muscle movements, mood, planning for the future, setting goals, and judging priorities.

Hippocampus: Plays a significant role in the formation of long-term memories.

Medulla Oblongata: Contains centers for the control of vital processes such as heart rate, respiration, blood pressure, and swallowing.

Limbic System: A group of interconnected structures that mediate emotions, learning and memory.

Occipital Lobe: Helps process visual information.

Parahippocampal Gyrus: An important connecting pathway of the limbic system.

Parietal Lobe: Receives and processes information about temperature, taste, touch, and movement coming from the rest of the body. Reading and arithmetic are also processed in this region.

Pons: Contains centers for the control of vital processes, including respiration and cardiovascular functions. It also is involved in the coordination of eye movements and balance.

Temporal Lobe: Processes hearing, memory and language functions.

Thalamus: A major relay station between the senses and the cortex (the outer layer of the brain consisting of the parietal, occipital, frontal and temporal lobes).

Resources

• Alzheimer’s Disease Toolkit (Helpful Information to Understand and Manage Alzheimer's Disease)
• Expert Information on Alzheimer's Disease (Articles)
• Alzheimer's Disease Facts and Data (Fact Sheets)